B.S., 1990, Mankato State University
Ph.D., 1994, Iowa State University
Postdoctoral, 1995-98, University of Minnesota
Positions are available for new graduate students in the Berreau lab. Please contact Dr. Berreau for information about the application process. (firstname.lastname@example.org).
The Berreau laboratory is interested in the role
that metal ions play in human health, the environment, and catalysis.
Our research is directed at understanding metal-promoted reactions that
involve naturally occurring small organic molecules. The goal is to
determine the fundamental chemical principles that control such
reactions, so that this knowledge can be used to design new compounds
that benefit human life.
Outlined below are areas of current interest:
1) CO-releasing molecules
Carbon monoxide is generally thought of a toxic
small molecule. However, recent studies indicate that a low
concentration, CO is an important signaling molecule in humans and is
known to dilate blood vessels and have anti-inflammatory effects. Based
on these properties, an area of emerging research is the development of
CO-releasing molecules for the controlled delivery of a specific amount
of CO. We are contributing to this area through studies of the photoinduced CO-release reactivity of flavonols.
S. N. Anderson, J. M. Richards, H. J. Esquer, A. D. Benninghoff, A. M. Arif, and L. M. Berreau, "A Structurally-Tunable 3-Hydroxyflavone Motif for Visible Light-Induced Carbon Monoxide-Releasing Molecules (CORMs)," ChemistryOpen 2015, 4, 590-594.
S. L. Saraf, T. J. Fish, A. D. Benninghoff, A. A. Buelt, R. C. Smith and L. M. Berreau, "Photochemical Reactivity of RuII(η6-p-cymene) Flavonolato Compounds," Organometallics 2014, 33, 6341-6351.
S. N. Anderson, M. Noble, K. Grubel, B. Marshall, A. M. Arif, and L. M. Berreau, "Influence of Supporting Ligand Microenvironment on the Aqueous Stability and Visible-light Induced CO-release Reactivity of Zinc Flavonolato Species," J. Coord. Chem. 2014, 67, 4061-4075.
K. Grubel, S. L. Saraf, S. N. Anderson, B. J. Laughlin, R. C. Smith, A. M. Arif, and L. M. Berreau, "Synthesis, Characterization, and Photoinduced CO-release Reactivity of a Pb(II) Flavonolate Complex: Comparisons to Group 12 Analogs," Inorg. Chim. Acta 2013, 407, 91-97.
K. Grubel, A. M. Marts, S. M. Greer, D. L. Tierney, C. J. Allpress, S. N. Anderson, B. J. Laughlin, R. C. Smith, A. M. Arif, and L. M. Berreau, "Photoinitiated Dioxygenase-type Reactivity of Open-Shell 3d Divalent Metal Flavonolato Complexes," Eur. J. Inorg. Chem. 2012, 4750-4757.
K. Grubel, B. J. Laughlin, T. R. Maltais, R. C. Smith, A. M. Arif, and L. M. Berreau, “Photochemically-induced Dioxygenase-type CO-release Reactivity of Group 12 Metal Flavonolate Complexes,” Chem. Commun.
2011, 47, 10431-10433.
K. Grubel, K. Rudzka, A. M. Arif, K. L. Klotz, J.
A. Halfen, and L. M.
Berreau, “Synthesis, Characterization, and Ligand
of a Series of First Row Divalent Metal
Complexes,” Inorg. Chem. 2010, 49, 82-96.
2) Aliphatic carbon-carbon bond cleavage reactivity
C. J. Allpress and L. M. Berreau, "A Nickel-containing Model System of Acireductone Dioxygenase that Utilizes a C(1)-H Acireductone Substrate," Eur. J. Inorg. Chem. 2014, 4642-4649.
C. J. Allpress, A. Milaczewska, T. Borowski, J. R. Bennett, D. L. Tierney, A. M. Arif, L. M. Berreau, "Halide-promoted Dioxygenolysis of a Carbon-carbon Bond by a Copper(II) Diketonate Complex," J. Am. Chem. Soc. 2014, 136, 7821-7824.
C. J. Allpress and L. M. Berreau, "Oxidative Aliphatic Carbon-carbon Bond Cleavage Reactivity," Coord. Chem. Rev. 2013, 257, 3005-3029.
C. J. Allpress, K. Grubel, E. Szajna-Fuller, A. M. Arif, and L. M.
Berreau, "Regioselective Aliphatic Carbon-Carbon Bond Cleavage by a
Model System of Relevance to Iron-containing Acireductone Dioxygenase," J. Am. Chem. Soc. 2013, 135, 659-668.
C. J. Allpress, A. M. Arif, D. T. Houghton, and L. M. Berreau,
"Photochemically-initiated Oxidative Carbon-carbon Bond Cleavage
Reactivity in Chlorodiketonate NiII Complexes," Chemistry – A European Journal 2011, 17, 14962-14973.
K. Grubel, G. K. Ingle, A. L. Fuller, A. M. Arif, and L. M. Berreau, “Influence of Water on the Formation of O2-reactive Divalent Metal Enolate Complexes of Relevance to Acireductone Dioxygenases,” Dalton Trans. 2011, 40 , 10609-10620.
L. M. Berreau, T. Borowski, K. Grubel, C. J. Allpress, J. P. Wikstrom,
M. E. Germain, E. V. Rybak-Akimova, and D. L. Tierney, “Mechanistic
Studies of the O2-dependent Aliphatic Carbon-carbon Bond Cleavage Reaction of a Nickel Enolate Complex,” Inorg. Chem. 2011, 50, 1047-1057.
K. Rudzka, K. Grubel, A. M. Arif, and L. M.
Enediolate Cluster Generated in an Acireductone
Reaction," Inorg. Chem. 2010, 49, 7623-7625.
K. Grubel, A. L. Fuller, B. M. Chambers, A. M. Arif and L. M. Berreau, “O2-Dependent
Aliphatic Carbon-carbon Bond Cleavage Reactivity in a Ni(II) Enolate
Complex Having a Hydrogen Bond Donor Microenvironment; Comparison with a
Hydrophobic Analog,” Inorg. Chem. 2010, 49, 1071-1081.
K. Rudzka, A. M. Arif, L. M. Berreau, “A Trinuclear Ni(II) Enediolate Complex: Synthesis, Characterization, and O2 Reactivity,” Inorg. Chem. 2008, 47, 10832-10840.
E. Szajna-Fuller, K. Rudzka, A. M. Arif, L. M.
“Acireductone Dioxygenase-type Reactivity for a Ni(II) Complex
Monoanionic Coordination of a Model Substrate: Product
and a Stuctural Requirement for Reactivity,” Inorg. Chem. 2007, 46, 5499-5507.
E. Szajna-Fuller, B. M. Chambers, A. M. Arif, L.
“Carboxylate Coordination Chemistry of a Mononuclear Ni(II)
Center in a
Hydrophobic or Hydrogen Bond Donor Secondary Environment:
Acireductone Dioxygenase,” Inorg. Chem. 2007, 46, 5486-5498.
E. Szajna, A. M. Arif, L. M. Berreau, “Aliphatic
Cleavage Reactivity of a Mononuclear Ni(II)
in the Presence of Base and O2: A Model Reaction for Acireductone Dioxygenase (ARD),” J. Am. Chem. Soc. 2005, 127, 17186-17187.
3) Zinc-promoted catalysis in biological systems; relationships to therapeutic targets and metal ion toxicity
Metal ions play important roles in catalysis in biological systems, with one of the most abundant metal ions being Zn(II). By studying chemical
reactions of relevance to those catalyzed by zinc enzymes, our goal is to provide detailed chemical insight that may assist in the development of new therapeutics and contribute toward understanding metal ion toxicity (upon replacement of Zn(II)).
E. S. Elton, T. Zhang, R. Prabhakar, A. M. Arif, and L. M. Berreau, "Pb(II)-promoted Amide Cleavage: Mechanistic Comparison to a Zn(II) Analog," Inorg. Chem. 2013, 52, 11480-11492.
L. M. Berreau, "Zinc in Biology", In Comprehensive Inorganic Chemistry II, J. Reedijk and K. Poeppelmeier, Eds., Elsevier, 2013, pp. 179-205.
J. J. Danford, A. M. Arif, and L. M. Berreau, “Thioester Hydrolysis Promoted by a Mononuclear Zinc Complex,” Inorg. Chem. 2010, 49, 778-780.
J. J. Danford, P. Dobrowolski, and L. M. Berreau, "Thioester Hydrolysis Reactivity of an Fe(III)Zn(II) Complex," Inorg. Chem. 2009, 48, 11352 -11361.
K. Rudzka, A. M. Arif, L. M. Berreau, “Glyoxalase
I-type Hemithioacetal Isomerization Reactivity of a Mononuclear Ni(II)
Deprotonated Amide Complex,” J. Am. Chem. Soc. 2006, 128, 17018-17023.
L. M. Berreau, A. Saha, A. M. Arif, “Thioester
Hydrolysis Reactivity of Binuclear Zinc Hydroxide Complexes:
Investingating Reactivity Relevant to Glyoxalase II Enzymes,” Dalton Trans. 2006, 183-192.